8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside

Base Information

• Chemical Name: 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside
• CAS No.: 1323024-80-1
• Molecular Formula: C₄₁H₅₀BrCl₃N₄O₁₂
• Molecular Weight: 977.131
• Mol file: 1323024-80-1.mol

Synonyms:8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside

Chemical Property of 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside

There total 8 articles about 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl)-β-D-glucopyranoside (1323024-79-8) → 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside (1323024-80-1)

Guidance literature:

With acetic acid; In water; at 50 ℃; for 0.666667h;

DOI:10.1016/j.carres.2011.02.011

Reference yield:

C20H32BrCl3N4O12 → 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside (1323024-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 10-camphorsufonic acid / acetonitrile / 2 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / -25 °C

2.2: 0.67 h / -25 - 20 °C

3.1: acetic acid / water / 0.67 h / 50 °C

With 10-camphorsufonic acid; sodium hydride; acetic acid; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.carres.2011.02.011

Reference yield:

8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside (1323024-76-5) → 8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside (1323024-80-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; barium carbonate / tetrachloromethane; 1,1,2,2-tetrachloroethane / 2 h / 100 °C

2.1: sodium methylate / methanol

2.2: amberlite IR-120

3.1: 10-camphorsufonic acid / acetonitrile / 2 h

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / -25 °C

4.2: 0.67 h / -25 - 20 °C

5.1: acetic acid / water / 0.67 h / 50 °C

With N-Bromosuccinimide; 10-camphorsufonic acid; sodium methylate; sodium hydride; acetic acid; barium carbonate; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1,1,2,2-tetrachloroethane;

DOI:10.1016/j.carres.2011.02.011

upstream raw materials:

8-azido-3,6-dioxaoctyl 6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl)-β-D-glucopyranoside

8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3-di-O-benzyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl)-β-D-glucopyranoside

8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside

8-azido-3,6-dioxaoctyl 4-O-benzoyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside

Downstream raw materials:

8-azido-3,6-dioxaoctyl 4-O-benzyl-6-bromo-2,6-dideoxy-2-trichloroacetamido-3-O-(benzyl 2,3-di-O-benzyl-β-D-galactopyranosyluronate)-β-D-glucopyranoside