Technology Process of (R)-(3-(benzyloxy)-5-(2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)isoxazol-4-yl)methanol
There total 4 articles about (R)-(3-(benzyloxy)-5-(2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)isoxazol-4-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexane; toluene;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol302691j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dimethyl zinc(II); ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol) / toluene / 36 h / 20 °C / Inert atmosphere
2: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h / 0 °C / Inert atmosphere
3: potassium hydrogencarbonate; N-chloro-succinimide / ethyl acetate / 120 h / 20 - 48 °C / Inert atmosphere
4: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere
With
1H-imidazole; N-chloro-succinimide; dimethyl zinc(II); diisobutylaluminium hydride; potassium hydrogencarbonate; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol);
In
hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol302691j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h / 0 °C / Inert atmosphere
2: potassium hydrogencarbonate; N-chloro-succinimide / ethyl acetate / 120 h / 20 - 48 °C / Inert atmosphere
3: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere
With
1H-imidazole; N-chloro-succinimide; diisobutylaluminium hydride; potassium hydrogencarbonate;
In
hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol302691j
