1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Base Information

• Chemical Name: 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole
• CAS No.: 155261-36-2
• Molecular Formula: C₁₉H₁₇N₃O₂
• Molecular Weight: 319.363
• Mol file: 155261-36-2.mol

Synonyms:1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Chemical Property of 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

There total 7 articles about 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole (155261-42-0) → 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole (155261-36-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; Heating;

DOI:10.1021/jo00086a028

Reference yield: 97.0%

1-<4-(Methoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole (155261-38-4) → 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole (155261-36-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; Heating;

DOI:10.1021/jo00086a028

Reference yield:

pyridine-2-carbonyl chloride (29745-44-6) → 1-(4-Carboxyphenyl)-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole (155261-36-2)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / Ambient temperature

2: 94 percent / hydrazine hydrate / CH₂Cl₂

3: 52 percent / K₂CO₃ / dimethylsulfoxide / 72 h / 120 - 140 °C

4: 97 percent / 10percent NaOH / tetrahydrofuran / Heating

With sodium hydroxide; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo00086a028

upstream raw materials:

2-Picolinoylcyclohexanone

4-Hydrazinobenzoic acid

1-<4-(Methoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole