2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

Base Information

Chemical Name:2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester
CAS No.:1316741-89-5
Molecular Formula:C₂₈H₂₇N₃O₄
Molecular Weight:469.54
Hs Code.:

Synonyms:2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

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Chemical Property of 2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

Chemical Property:

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Technology Process of 2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

There total 7 articles about 2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58881-45-1
Indole-2-carbonyl chloride

: 1316742-32-1
2-(RS)-(2-aminobenzoylamino)-4-phenylbutyric acid ethyl ester

: 1316741-89-5
2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm200438b

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1316741-89-5
2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride; acetyl chloride / 3.5 h / 0 - 20 °C

2: pyridine / dichloromethane / 0 - 20 °C

With pyridine; phosphorus pentachloride; acetyl chloride; In dichloromethane;
DOI:10.1021/jm200438b

Reference yield:

: 17376-04-4
2-phenethyl iodide

: 1316741-89-5
2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 0.5 h / Reflux

1.2: Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / Reflux

3.1: hydrogenchloride / 0.5 h

4.1: triethylamine / ethyl acetate / 4 h / Reflux

5.1: pyridine / dichloromethane / 0 - 20 °C

With pyridine; hydrogenchloride; sodium ethanolate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm200438b