2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide

Base Information

• Chemical Name: 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide
• CAS No.: 83473-46-5
• Molecular Formula: C₂₂H₃₁N₃O₃S
• Molecular Weight: 417.572

Synonyms:2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide

Chemical Property of 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide

Chemical Property:

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Technology Process of 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide

There total 5 articles about 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

p-toluenesulfonyl chloride (98-59-9) + 2-Dimethylamino-pentanoic acid (4-amino-2,6-dimethyl-phenyl)-amide (83473-73-8) → 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide (83473-46-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 5 ℃;

DOI:10.1002/jps.2600710619

Reference yield:

2-Bromovaleric acid (584-93-0) → 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide (83473-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / PCl₃ / benzene / 3 h / Heating

2: 82 percent / NaHCO₃ / benzene / 144 h / Heating

3: 70 percent / Fe, conc. HCl / ethanol; H₂O / 0.58 h / Heating

4: 62 percent / pyridine / CH₂Cl₂ / 0 - 5 °C

With pyridine; hydrogenchloride; iron; sodium hydrogencarbonate; phosphorus trichloride; In ethanol; dichloromethane; water; benzene;

DOI:10.1002/jps.2600710619

Reference yield:

2,6-dimethyl-4-nitroaniline (16947-63-0) → 2-Dimethylamino-pentanoic acid [2,6-dimethyl-4-(toluene-4-sulfonylamino)-phenyl]-amide (83473-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / PCl₃ / benzene / 3 h / Heating

2: 82 percent / NaHCO₃ / benzene / 144 h / Heating

3: 70 percent / Fe, conc. HCl / ethanol; H₂O / 0.58 h / Heating

4: 62 percent / pyridine / CH₂Cl₂ / 0 - 5 °C

With pyridine; hydrogenchloride; iron; sodium hydrogencarbonate; phosphorus trichloride; In ethanol; dichloromethane; water; benzene;

DOI:10.1002/jps.2600710619

upstream raw materials:

p-toluenesulfonyl chloride

2-Dimethylamino-pentanoic acid (4-amino-2,6-dimethyl-phenyl)-amide

2-Bromovaleric acid

2,6-dimethyl-4-nitroaniline

Downstream raw materials:

2-Dimethylamino-pentanoic acid {4-[butyl-(toluene-4-sulfonyl)-amino]-2,6-dimethyl-phenyl}-amide

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