N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

Base Information

Chemical Name:N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide
CAS No.:1201640-75-6
Molecular Formula:C₂₃H₃₅N₅O₄
Molecular Weight:445.562
Hs Code.:

Synonyms:N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

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Chemical Property of N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

Chemical Property:

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Technology Process of N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

There total 6 articles about N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201640-74-5
3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanoic acid

: 99863-45-3
N-(2,2-dimethoxyethyl)cyclohexanamine

: 1201640-75-6
N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

Guidance literature:: With 2-propane phosphonic acid anhydride; triethylamine; In tetrahydrofuran; acetonitrile; at 25 ℃; for 0.25h;

Reference yield:

: 1201640-34-7
tert-butyl 3-[2-(3-bromophenyl)ethoxy]propanoate

: 1201640-75-6
N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 130 °C / Inert atmosphere

2: sodium azide; triethylamine hydrochloride / tert-butyl alcohol / 2 h / 140 °C / Microwave irradiation

3: methanol / dichloromethane / 0.25 h / Cooling with ice

4: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

5: 2-propane phosphonic acid anhydride; triethylamine / tetrahydrofuran; acetonitrile / 0.25 h / 25 °C

With methanol; sodium azide; 2-propane phosphonic acid anhydride; triethylamine hydrochloride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 28229-69-8
2-(3-bromophenyl)ethan-1-ol

: 1201640-75-6
N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-benzyl-trimethylammonium hydroxide / methanol; toluene / 24 h

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 130 °C / Inert atmosphere

3: sodium azide; triethylamine hydrochloride / tert-butyl alcohol / 2 h / 140 °C / Microwave irradiation

4: methanol / dichloromethane / 0.25 h / Cooling with ice

5: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

6: 2-propane phosphonic acid anhydride; triethylamine / tetrahydrofuran; acetonitrile / 0.25 h / 25 °C

With methanol; sodium azide; 2-propane phosphonic acid anhydride; triethylamine hydrochloride; N-benzyl-trimethylammonium hydroxide; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;