17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

Base Information

Chemical Name:17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione
CAS No.:128802-59-5
Molecular Formula:C₃₀H₃₅F₃O₆
Molecular Weight:548.6
Hs Code.:

Synonyms:17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

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Chemical Property of 17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

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Technology Process of 17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

There total 12 articles about 17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 128802-55-1
17α-Hydroxy-17β-(hydroxymethyl)androst-4-ene-3,11-dione

: 128802-59-5
17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jo00308a022

Reference yield:

: 3597-44-2
17-hydroxy-3,11-dioxoandrost-4-ene-17-carboxylic acid

: 128802-59-5
17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / CHCl₃; diethyl ether / 1 h / 0 °C

2: 98 percent / D-Camphor-10-sulfonic acid / benzene / 12 h / Heating

3: 84 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

4: 98 percent / D-camphor-10-sulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

5: 95 percent / pyridinium dichromate / CH₂Cl₂ / 5 h / Ambient temperature

6: 98 percent / aq. HCl / methanol / 2 h / Ambient temperature

7: 99 percent / NEt₃, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; triethylamine; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1021/jo00308a022

Reference yield:

: 3941-62-6
Methyl 17α-Hydroxy-3,11-dioxoandrost-4-ene-17β-carboxylate

: 128802-59-5
17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / D-Camphor-10-sulfonic acid / benzene / 12 h / Heating

2: 84 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

3: 98 percent / D-camphor-10-sulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

4: 95 percent / pyridinium dichromate / CH₂Cl₂ / 5 h / Ambient temperature

5: 98 percent / aq. HCl / methanol / 2 h / Ambient temperature

6: 99 percent / NEt₃, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; triethylamine; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00308a022