Technology Process of 17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione
There total 12 articles about 17α-Hydroxy-17β-<<(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy>methyl>androst-4-ene-3,11-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1021/jo00308a022
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / CHCl3; diethyl ether / 1 h / 0 °C
2: 98 percent / D-Camphor-10-sulfonic acid / benzene / 12 h / Heating
3: 84 percent / LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
4: 98 percent / D-camphor-10-sulfonic acid / CH2Cl2 / 1 h / Ambient temperature
5: 95 percent / pyridinium dichromate / CH2Cl2 / 5 h / Ambient temperature
6: 98 percent / aq. HCl / methanol / 2 h / Ambient temperature
7: 99 percent / NEt3, DMAP / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; triethylamine;
camphor-10-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1021/jo00308a022
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / D-Camphor-10-sulfonic acid / benzene / 12 h / Heating
2: 84 percent / LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
3: 98 percent / D-camphor-10-sulfonic acid / CH2Cl2 / 1 h / Ambient temperature
4: 95 percent / pyridinium dichromate / CH2Cl2 / 5 h / Ambient temperature
5: 98 percent / aq. HCl / methanol / 2 h / Ambient temperature
6: 99 percent / NEt3, DMAP / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; triethylamine;
camphor-10-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00308a022