8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

Base Information

Chemical Name:8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline
CAS No.:1235454-79-1
Molecular Formula:C₁₇H₁₁F₃N₄
Molecular Weight:328.296
Hs Code.:

Synonyms:8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

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Chemical Property of 8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

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Technology Process of 8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

There total 5 articles about 8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1235454-44-0
2-iodo-4-methyl-N-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)aniline

: 1235454-79-1
8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

Guidance literature:: With copper(l) iodide; sodium azide; L-proline; In dimethyl sulfoxide; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/adsc.200900875

Reference yield:

: 887144-94-7
Togni's reagent II

: C₁₆H₁₂N₄

: 1235454-79-1
8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

Guidance literature:: With tetra-(n-butyl)ammonium iodide; In dimethyl sulfoxide; at 85 ℃; for 10h; Inert atmosphere; Schlenk technique;
DOI:10.1039/c6cc08543a

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1235454-79-1
8-methyl-3-phenyl-4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxaline

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilylazide; copper(I) bromide; tert.-butylhydroperoxide / water; acetonitrile / 3 h / 30 °C / Schlenk technique; Inert atmosphere

2: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dichloromethane / 24 h / Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 3 h / 25 °C / Schlenk technique; Inert atmosphere

4: tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 10 h / 85 °C / Inert atmosphere; Schlenk technique

With tert.-butylhydroperoxide; trimethylsilylazide; N-benzyl-N,N,N-triethylammonium chloride; tetra-(n-butyl)ammonium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1039/c6cc08543a