[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane
CAS No.:132375-61-2
Molecular Formula:C₃₀H₄₂O₄Si
Molecular Weight:494.747
Hs Code.:

Synonyms:[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

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Chemical Property of [3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

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Technology Process of [3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

There total 4 articles about [3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 132375-60-1
3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propan-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 132375-61-2
[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 2h;

Reference yield:

: 132375-56-5
((3aR,4R,6S,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-methanol

: 132375-61-2
[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMSO, NEt₃ / CH₂Cl₂ / 1 h / -78 °C

2: CH₂Cl₂ / 18 h / 25 °C

3: 1) L-selectride, t-BuOH, 2) NaOH, H₂O₂ / 1) THF, -78 deg C, 1 h, 2) 0 deg C, 1 h

4: DIBAH / CH₂Cl₂ / 1 h / -78 °C

5: 95 percent / imidazole / dimethylformamide / 2 h / 0 - 25 °C

With 1H-imidazole; sodium hydroxide; oxalyl dichloride; dihydrogen peroxide; L-Selectride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 132375-58-7
(E)-3-((3aR,4R,6S,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-acrylic acid methyl ester

: 132375-61-2
[3-((3aR,4R,6R,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 1) L-selectride, t-BuOH, 2) NaOH, H₂O₂ / 1) THF, -78 deg C, 1 h, 2) 0 deg C, 1 h

2: DIBAH / CH₂Cl₂ / 1 h / -78 °C

3: 95 percent / imidazole / dimethylformamide / 2 h / 0 - 25 °C

With 1H-imidazole; sodium hydroxide; dihydrogen peroxide; L-Selectride; diisobutylaluminium hydride; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide;