(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Base Information

Chemical Name:(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate
CAS No.:1262235-14-2
Molecular Formula:C₂₈H₃₉BrO₈
Molecular Weight:583.517
Hs Code.:

Synonyms:(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Suppliers and Price of (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

There total 11 articles about (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1262235-05-1
(R,Z)-5-bromopent-4-en-2-ol

: 1262235-04-0
2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoic acid

: 1262235-14-2
(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.10.092

Reference yield:

: 603039-01-6
((4R,5S)-5-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl pivalate

: 1262235-14-2
(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diethylamine / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C / Inert atmosphere

2.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; diethylamine; triphenylphosphine; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane; water; 4.1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2010.10.092

Reference yield:

: 603039-00-5
((4R,5S)-5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl pivalate

: 1262235-14-2
(S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium; diethylamine / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

3.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; diethylamine; triphenylphosphine; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane; water; 5.1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2010.10.092