N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide
CAS No.:1394910-41-8
Molecular Formula:C₂₀H₂₉N₃O
Molecular Weight:327.47
Hs Code.:

Synonyms:N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

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Chemical Property of N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

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Technology Process of N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

There total 9 articles about N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₇N₃O₃

: 1394910-41-8
N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2012.07.028

Reference yield:

: 223505-12-2
(1R,3R,4S)-2-<(1S)-phenylethyl>-2-aza-bicyclo<2.2.1>hept-5-ene-3-carboxylic acid ethyl ester

: 1394910-41-8
N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen; potassium carbonate

2: lithium aluminium tetrahydride

3: hydrogen azide; triphenylphosphine; diethylazodicarboxylate / toluene; benzene / Inert atmosphere

4: triphenylphosphine / methanol / Reflux

5: potassium carbonate; dicyclohexyl-carbodiimide / acetonitrile / 24 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium aluminium tetrahydride; hydrogen azide; palladium on activated charcoal; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In methanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/j.tet.2012.07.028

Reference yield:

: 215674-16-1
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-hydroxymethyl-2-azabicyclo[2.2.1]heptane

: 1394910-41-8
N-((1S,4S,5R)-2-((S)-1-phenylethyl)-2-azabicyclo[3.2.1]octan-4-yl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen azide; triphenylphosphine; diethylazodicarboxylate / toluene; benzene / Inert atmosphere

2: triphenylphosphine / methanol / Reflux

3: potassium carbonate; dicyclohexyl-carbodiimide / acetonitrile / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogen azide; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In methanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/j.tet.2012.07.028