Technology Process of 5-(4-methoxyphenyl)-3-methylpentanal
There total 4 articles about 5-(4-methoxyphenyl)-3-methylpentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jo300635m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: oxalyl dichloride; dimethyl sulfoxide; triethylamine / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / -78 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
3: Swern oxidation;
DOI:10.1021/jo300635m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 18 h
2.1: palladium 10% on activated carbon; hydrogen / ethanol
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / -78 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; mineral oil;
4.1: Swern oxidation;
DOI:10.1021/jo300635m
