(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

Base Information

Chemical Name:(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde
CAS No.:233255-57-7
Molecular Formula:C₂₆H₃₂O₆
Molecular Weight:440.536
Hs Code.:

Synonyms:(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

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Chemical Property of (2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

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Technology Process of (2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

There total 7 articles about (2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 233255-56-6
7,8-dideoxy-2-O-methyl-4,5-O-(1-methylethylidene)-3,6-bis-O-(phenylmethyl)-D-glycero-D-manno-oct-7-enitol

: 233255-57-7
(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

Guidance literature:: With molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1081/CAR-120004333

Reference yield:

: 233255-54-4
7,8-dideoxy-1-O-[(1,1-dimethylethyl)diphenylsilyl]-4,5-O-(1-methylethylidene)-3,6-bis-O-(phenylmethyl)-D-glycero-D-manno-oct-7-enitol

: 233255-57-7
(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaH; Bu₄NI / tetrahydrofuran / 15 h / 20 °C

2: 92 percent / TBAF / tetrahydrofuran / 24 h / 20 °C

3: 93 percent / PCC; AcONa; molecular sieves / CH₂Cl₂ / 4 h / 20 °C

With molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1081/CAR-120004333

Reference yield:

: 126138-78-1
7,8-dideoxy-4,5-O-(1-methylethylidene)-3,6-bis-O-(phenylmethyl)-D-glycero-D-manno-oct-7-enitol

: 233255-57-7
(2S,3S)-3-Benzyloxy-3-[(4S,5R)-5-((R)-1-benzyloxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methoxy-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 4-dimethylaminopyridine / pyridine / 24 h / 20 °C

2: 74 percent / NaH; Bu₄NI / tetrahydrofuran / 15 h / 20 °C

3: 92 percent / TBAF / tetrahydrofuran / 24 h / 20 °C

4: 93 percent / PCC; AcONa; molecular sieves / CH₂Cl₂ / 4 h / 20 °C

With dmap; molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1081/CAR-120004333