Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

Base Information

Chemical Name:Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester
CAS No.:132148-56-2
Molecular Formula:C₂₈H₃₂N₂O₃
Molecular Weight:444.574
Hs Code.:

Synonyms:Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

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Chemical Property of Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

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Technology Process of Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

There total 6 articles about Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 132148-55-1
2-(9-Benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butan-1-ol

: 132148-56-2
Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

Guidance literature:: With pyridine; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90085-7

Reference yield:

: 41339-61-1
5-benzyloxy-3-(2-hydroxyethyl)indole

: 132148-56-2
Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / diethyl ether / 1.) -5 deg C, 1.5 h 2.) refrigerator, overnight;

2: 96 percent

3: 98 percent / 6N HCl, KCN, NaBH₄ / H₂O; diethyl ether; methanol / 3.5 h / Ambient temperature

4: 66 percent / 50percent acetic acid / 72 h / Ambient temperature

5: 94 percent / pyridine / 24 h / Ambient temperature

With pyridine; hydrogenchloride; potassium cyanide; sodium tetrahydroborate; acetic acid; In methanol; diethyl ether; water;
DOI:10.1016/S0040-4020(01)90085-7

Reference yield:

: 4382-53-0
2-(5-benzyloxy-1H-indol-3-yl)acetic acid

: 132148-56-2
Acetic acid 2-(9-benzyloxy-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizin-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 3.5 h / Ambient temperature

2: 51 percent / diethyl ether / 1.) -5 deg C, 1.5 h 2.) refrigerator, overnight;

3: 96 percent

4: 98 percent / 6N HCl, KCN, NaBH₄ / H₂O; diethyl ether; methanol / 3.5 h / Ambient temperature

5: 66 percent / 50percent acetic acid / 72 h / Ambient temperature

6: 94 percent / pyridine / 24 h / Ambient temperature

With pyridine; hydrogenchloride; potassium cyanide; sodium tetrahydroborate; lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1016/S0040-4020(01)90085-7