(2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

Base Information

• Chemical Name: (2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride
• CAS No.: 1193335-92-0
• Molecular Formula: C₂₈H₃₁F₇N₄O₂*ClH
• Molecular Weight: 625.03

Synonyms:(2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

Chemical Property of (2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride

There total 10 articles about (2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (1193335-91-9) → (2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride (1193335-92-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 0.5h;

Reference yield:

(2R)-2-(4-fluoro-2-methylphenyl)-4-oxo-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (629955-21-1) → (2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride (1193335-92-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: ammonia / methanol / 0.25 h / 20 °C

1.2: 20 °C

2.1: dichloromethane / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

3.2: pH 8

4.1: triethylamine / ethyl acetate / 0 °C

4.2: 0 °C / Reflux

5.1: ozone / dichloromethane / -78 °C / Inert atmosphere

5.2: -78 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1 h / 0 °C

6.2: 0 - 25 °C

6.3: 0 °C

7.1: hydrogen; cesium fluoride / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

8.1: ammonia / methanol / Sealed tube

9.1: hydrogenchloride / diethyl ether / 0.5 h

With hydrogenchloride; ammonia; hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In methanol; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

1,1-dimethylethyl (2R,4S)-4-amino-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-1-piperidinecarboxylate (1193336-39-8) → (2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride (1193335-92-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: dichloromethane / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

2.2: pH 8

3.1: triethylamine / ethyl acetate / 0 °C

3.2: 0 °C / Reflux

4.1: ozone / dichloromethane / -78 °C / Inert atmosphere

4.2: -78 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1 h / 0 °C

5.2: 0 - 25 °C

5.3: 0 °C

6.1: hydrogen; cesium fluoride / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

7.1: ammonia / methanol / Sealed tube

8.1: hydrogenchloride / diethyl ether / 0.5 h

With hydrogenchloride; ammonia; hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In methanol; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

(2S,5S,7R)-N₈-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N₈-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide

(2R)-2-(4-fluoro-2-methylphenyl)-4-oxo-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

3,5-bis(trifluoromethyl)-α-methyl-N-methylbenzylamine

1,1-dimethylethyl (2R,4S)-4-amino-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-1-piperidinecarboxylate

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