(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

Base Information

Chemical Name:(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride
CAS No.:1361001-91-3
Molecular Formula:C₂₄H₁₆ClFO
Molecular Weight:374.842
Hs Code.:

Synonyms:(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

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Technology Process of (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

There total 3 articles about (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1049800-47-6
(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetic acid

: 1361001-91-3
(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201528b

Reference yield:

: 1481-32-9
6-fluoroindan-1-one

: 1361001-91-3
(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

2.2: 20 - 70 °C

2.3: 20 °C / pH 1 - 2

3.1: hydrogenchloride / water / 20 °C

4.1: oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; toluene-4-sulfonic acid; calcium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jm201528b

Reference yield:

: 162548-68-7
ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)acetate

: 1361001-91-3
(E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

1.2: 20 - 70 °C

1.3: 20 °C / pH 1 - 2

2.1: hydrogenchloride / water / 20 °C

3.1: oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; toluene-4-sulfonic acid; calcium chloride; In dichloromethane; water; toluene;
DOI:10.1021/jm201528b