(S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde

Base Information

• Chemical Name: (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde
• CAS No.: 149180-87-0
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 149180-87-0.mol

Synonyms:(S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde

Chemical Property of (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde

There total 5 articles about (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloride (100-44-7) → (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde (149180-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH, imidazole / dimethylformamide

2: 1.) O₃, 2.) PPH₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂

With 1H-imidazole; sodium hydride; ozone; triphenylphosphine; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3773(19980619)37:11<1566::AID-ANIE1566>3.0.CO;2-U

Reference yield:

(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-4-en-1-ol (186258-69-5) → (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde (149180-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH, imidazole / dimethylformamide

2: 1.) O₃, 2.) PPH₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂

With 1H-imidazole; sodium hydride; ozone; triphenylphosphine; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3773(19980619)37:11<1566::AID-ANIE1566>3.0.CO;2-U

Reference yield:

2,3-isopropylidene-glyceraldehyde (15186-48-8) → (S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde (149180-87-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / -30 °C

2: NaH, imidazole / dimethylformamide

3: 1.) O₃, 2.) PPH₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂

With 1H-imidazole; sodium hydride; ozone; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3773(19980619)37:11<1566::AID-ANIE1566>3.0.CO;2-U

upstream raw materials:

benzyl chloride

(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-4-en-1-ol

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

2,3-dideoxy-5,6-O-(1-methylethylidene)-4-O-bnezyl-D-erythro-hexitol

(S)-6-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hex-1-en-3-ol

(E)-(S)-8-Benzyloxy-8-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-oct-4-enoic acid ethyl ester