(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

Base Information

Chemical Name:(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide
CAS No.:1344699-11-1
Molecular Formula:C₂₁H₂₃N₃O₆
Molecular Weight:413.43
Hs Code.:

Synonyms:(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

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Chemical Property of (2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

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Technology Process of (2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

There total 7 articles about (2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1344700-77-1
(2S)-2-[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}benzoyl)(methyl)amino]-N,2-dimethyl-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide

: 1344699-11-1
(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

Guidance literature:: With sulfuric acid; In 1,4-dioxane; water; at 20 ℃; for 3.75h; Cooling;

Reference yield:

: 21921-76-6
4-bromo-2-furancarbaldehyde

: 1344699-11-1
(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Cooling with ice

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.66 h / 20 °C / Cooling with ice

3.1: acetic acid butyl ester; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 7.5 h / 110 °C / Inert atmosphere

3.2: 1 h / 20 °C / Cooling with ice

4.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere

5.1: sulfuric acid / water; 1,4-dioxane / 3.75 h / 20 °C / Cooling

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; acetic acid butyl ester; sulfuric acid; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 59413-71-7
(4-bromofuran-2-yl)methanol

: 1344699-11-1
(2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.66 h / 20 °C / Cooling with ice

2.1: acetic acid butyl ester; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 7.5 h / 110 °C / Inert atmosphere

2.2: 1 h / 20 °C / Cooling with ice

3.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere

4.1: sulfuric acid / water; 1,4-dioxane / 3.75 h / 20 °C / Cooling

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic acid butyl ester; sulfuric acid; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;