C₂₆H₃₆F₃N₃O₅

Base Information

• Chemical Name: C₂₆H₃₆F₃N₃O₅
• CAS No.: 1357570-06-9
• Molecular Formula: C₂₆H₃₆F₃N₃O₅
• Molecular Weight: 527.584
• Mol file: 1357570-06-9.mol

Synonyms:C₂₆H₃₆F₃N₃O₅

Chemical Property of C₂₆H₃₆F₃N₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₂₆H₃₆F₃N₃O₅

There total 9 articles about C₂₆H₃₆F₃N₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S)-4-acetoxy-5,5,5-trifluoro-2-methylpentanoic acid (1357569-96-0) + C18H27N3O2*ClH → C26H36F3N3O5 (1357570-06-9)

Guidance literature:

(2S)-4-acetoxy-5,5,5-trifluoro-2-methylpentanoic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

C₁₈H₂₇N₃O₂*ClH; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1021/ol3000712

Reference yield:

benzyl (2S)-4-acetoxy-5,5,5-trifluoro-2-methylpentanoate (1357569-95-9) → C26H36F3N3O5 (1357570-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 23 °C

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.2: 0 - 23 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol3000712

Reference yield:

C23H35N3O4 (1357570-05-8) → C26H36F3N3O5 (1357570-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 23 °C

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.2: 0 - 23 °C / Inert atmosphere

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ol3000712

upstream raw materials:

benzyl (2S)-4-acetoxy-5,5,5-trifluoro-2-methylpentanoate

(2S)-4-acetoxy-5,5,5-trifluoro-2-methylpentanoic acid

C₂₃H₃₅N₃O₄

t-Boc-L-valine

Downstream raw materials:

C₂₄H₃₂F₃N₃O₄