C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

Base Information

• Chemical Name: C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine
• CAS No.: 59469-07-7
• Molecular Formula: C₁₆H₁₇ClFN₃
• Molecular Weight: 305.782
• Mol file: 59469-07-7.mol

Synonyms:C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

Chemical Property of C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

There total 3 articles about C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine (59467-64-0) → C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine (59469-07-7)

Guidance literature:

With potassium hydroxide; acetic acid; zinc; In dichloromethane; water; isopropyl alcohol;

Reference yield:

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2-(1-nitromethylene)-2H-1,4-benzodiazepine 4-oxide → C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine (59469-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum nickel / tetrahydrofuran; methanol

2: potassium hydroxide; acetic acid; zinc / dichloromethane; water; isopropyl alcohol

With potassium hydroxide; acetic acid; zinc; aluminum nickel; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

→ C-[7-chloro-5-(2-fluoro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine (59469-07-7)

Guidance literature:

DL-2-Aminomethyl-7-chlor-2,3-dihydro-5-<2-fluor-phenyl>-1H-1,4-benzodiazepin, Zn-Pulver/ Eg.;

upstream raw materials:

(7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine