4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole

Base Information

• Chemical Name: 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole
• CAS No.: 94418-12-9
• Molecular Formula: C₄₃H₃₉N₃O₅S
• Molecular Weight: 709.866
• Mol file: 94418-12-9.mol

Synonyms:4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole

Chemical Property of 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole

There total 1 articles about 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Diphenylmethyl 2-Bromo-2-methylpropionate (77497-42-8) + ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate (66338-99-6) → 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole (94418-12-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 6h; Ambient temperature;

DOI:10.1002/jhet.5570210435

Reference yield:

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole (94418-12-9) → triphenylmethyl alcohol (76-84-6) + 2-Amino-4-<(Z)-1-carboethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methylthiazole

Guidance literature:

With formic acid; In water; for 7h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1002/jhet.5570210435

Reference yield:

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole (94418-12-9) → 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>-methyl-2-chloroacetamidothiazole N-Oxide (94418-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 99percent formic acid / 1) 7 h, room temp., H₂O 2) 30 min., 0 deg C, dimethylacetamide 3) 1 h, room temper.

2: 76 percent / Permaleic Acid / CHCl₃ / 18 h / Ambient temperature

With formic acid; monopermaleic acid; In chloroform;

DOI:10.1002/jhet.5570210435

upstream raw materials:

Diphenylmethyl 2-Bromo-2-methylpropionate

ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate

Downstream raw materials:

triphenylmethyl alcohol

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>-methyl-2-chloroacetamidothiazole N-Oxide