ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

Base Information

Chemical Name:ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate
CAS No.:1028662-86-3
Molecular Formula:C₂₈H₃₄ClO₅PSi
Molecular Weight:545.087
Hs Code.:

Synonyms:ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

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Technology Process of ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

There total 3 articles about ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 872426-16-9
{2-[4-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethoxy-phenyl]-vinyl}-phosphonic acid diethyl ester

: 1028662-86-3
ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

Guidance literature:: With oxalyl dichloride; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jm050454c

Reference yield:

: 321558-45-6
diethyl (E)-2-(4-hydroxy-3,5-dimethoxyphenyl)vinylphosphonate

: 1028662-86-3
ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / N,N-dimethylaminopyridine; imidazole / dimethylformamide / 16 h / 20 °C

2: 100 percent / oxalyl chloride / CH₂Cl₂ / 20 h / 20 °C

With 1H-imidazole; dmap; oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050454c

Reference yield:

: 134-96-3
syringic aldehyde

: 1028662-86-3
ethyl (E)-2-(4-tert-butyldiphenylsilyloxy-3,5-dimethoxyphenyl)vinylphosphonochloridate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 1 h / -50 °C

1.2: 80 percent / tetrahydrofuran / 2 h / Heating

2.1: 57 percent / N,N-dimethylaminopyridine; imidazole / dimethylformamide / 16 h / 20 °C

3.1: 100 percent / oxalyl chloride / CH₂Cl₂ / 20 h / 20 °C

With 1H-imidazole; dmap; oxalyl dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050454c