(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

Base Information

Chemical Name:(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol
CAS No.:906535-64-6
Molecular Formula:C₂₂H₃₈O₅
Molecular Weight:382.541
Hs Code.:

Synonyms:(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

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Chemical Property of (3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

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Technology Process of (3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

There total 6 articles about (3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 906535-63-5
(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonanoic acid methyl ester

: 906535-64-6
(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/jo061098o

Reference yield:

: (2S,3S,5S)-2-Benzyloxymethoxy-7-methoxymethoxy-3,5-dimethyl-heptanal

: 906535-64-6
(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.68 g / CH₂Cl₂ / 18 h / 20 °C

2.1: CuI; LiBr / tetrahydrofuran / 0.33 h / -15 °C

2.2: 88 percent / TMSCl / tetrahydrofuran / 3 h / -78 °C

3.1: 87 percent / DIBAL-H / CH₂Cl₂ / 4 h / -78 °C

With copper(l) iodide; diisobutylaluminium hydride; lithium bromide; In tetrahydrofuran; dichloromethane; 1.1: Wittig olefination;
DOI:10.1021/jo061098o

Reference yield:

: 906535-61-3
(2S,3S,5S)-2-Benzyloxymethoxy-7-methoxymethoxy-3,5-dimethyl-heptan-1-ol

: 906535-64-6
(3R,4S,5S,7S)-4-Benzyloxymethoxy-9-methoxymethoxy-3,5,7-trimethyl-nonan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2.1: 1.68 g / CH₂Cl₂ / 18 h / 20 °C

3.1: CuI; LiBr / tetrahydrofuran / 0.33 h / -15 °C

3.2: 88 percent / TMSCl / tetrahydrofuran / 3 h / -78 °C

4.1: 87 percent / DIBAL-H / CH₂Cl₂ / 4 h / -78 °C

With copper(l) iodide; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 2.1: Wittig olefination;
DOI:10.1021/jo061098o