3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Base Information

Chemical Name:3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester
CAS No.:165801-63-8
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6<i>H</i>-imidazo[4,5-<i>d</i>][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Synonyms:3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Suppliers and Price of 3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

There total 9 articles about 3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 165801-63-8
3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

2: NaIO₄; RuO₂ / CCl₄; acetonitrile; H₂O / 0.25 h

3: NaBH₄ / methanol / 1 h / 20 °C

4: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

5: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 1551.49 Torr

6: Ph₃P; CBr₄ / CH₂Cl₂ / 0.5 h / 0 °C

7: NaH; NaI / dimethylformamide

8: NaBH₄ / methanol; CH₂Cl₂

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; hydrogen; sodium hydride; triphenylphosphine; sodium iodide; 10percent Pd/C; In methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Oxidation / 3: Reduction / 4: Alkylation / 5: Catalytic hydrogenation / 6: Bromination / 7: Alkylation / 8: Reduction;
DOI:10.1021/jm990448e

Reference yield:

: 3-bromo-5-(2-oxo-ethyl)-benzoic acid ethyl ester

: 165801-63-8
3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / methanol / 1 h / 20 °C

2: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

3: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 1551.49 Torr

4: Ph₃P; CBr₄ / CH₂Cl₂ / 0.5 h / 0 °C

5: NaH; NaI / dimethylformamide

6: NaBH₄ / methanol; CH₂Cl₂

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; hydrogen; sodium hydride; triphenylphosphine; sodium iodide; 10percent Pd/C; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Reduction / 2: Alkylation / 3: Catalytic hydrogenation / 4: Bromination / 5: Alkylation / 6: Reduction;
DOI:10.1021/jm990448e

Reference yield:

: 272130-67-3
ethyl 3-bromo-5-(1-propenyl)benzoate

: 165801-63-8
3-ethyl-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaIO₄; RuO₂ / CCl₄; acetonitrile; H₂O / 0.25 h

2: NaBH₄ / methanol / 1 h / 20 °C

3: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

4: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 1551.49 Torr

5: Ph₃P; CBr₄ / CH₂Cl₂ / 0.5 h / 0 °C

6: NaH; NaI / dimethylformamide

7: NaBH₄ / methanol; CH₂Cl₂

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; hydrogen; sodium hydride; triphenylphosphine; sodium iodide; 10percent Pd/C; In methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Oxidation / 2: Reduction / 3: Alkylation / 4: Catalytic hydrogenation / 5: Bromination / 6: Alkylation / 7: Reduction;
DOI:10.1021/jm990448e