N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide
CAS No.:916223-28-4
Molecular Formula:C₁₈H₁₆ClF₃N₂O₅S
Molecular Weight:464.85
Hs Code.:

Synonyms:N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Suppliers and Price of N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

There total 2 articles about N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916222-27-0
(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride

: 106-47-8
4-chloro-aniline

: 916223-28-4
N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In dichloromethane; for 2h;

Reference yield:

: 294843-47-3
N-((R)-3,4-dihydro-5-methoxy-2H-1-benzopyran-3-yl)trifluoroacetamide

: 916223-28-4
N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / chloroform / -15 °C

1.2: 3.17 h / 20 °C

2.1: pyridine / dichloromethane / 2 h

With pyridine; thionyl chloride; In dichloromethane; chloroform;

Reference yield: 72.0%

: 916223-28-4
N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide

: (3R)-3-amino-N-(4-chlorophenyl)-5-methoxychromane-8-sulfonamide

Guidance literature:: N-((3R)-8-{[(4-chlorophenyl)amino]sulfonyl}-5-methoxy-3,4-dihydro-2H-chromen-3-yl)-2,2,2-trifluoroacetamide; With sodium hydroxide; In methanol; water; for 168h;

With ammonium chloride; In methanol; water; pH=6.5;

With sodium carbonate; In water;