(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

Base Information

Chemical Name:(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane
CAS No.:112775-80-1
Molecular Formula:C₁₇H₂₄O₅S
Molecular Weight:340.441
Hs Code.:

Synonyms:(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

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Chemical Property of (1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

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Technology Process of (1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

There total 7 articles about (1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 112775-79-8
(1S,2R,4R,5R)-5-ethyl-2-methyl-4-hydroxymethyl-6,8-dioxabicyclo<3.2.1>octane

: 98-59-9
p-toluenesulfonyl chloride

: 112775-80-1
(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

Guidance literature:: With pyridine; dmap; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86814-9

Reference yield:

: 69743-60-8
(2S,3R)-threo-3-methylbutane-1,2,4-triol 1,2-acetonide

: 112775-80-1
(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / pyridine / 2 h / 0 °C

2: 98 percent / sodium iodide / acetone / 24 h

3: 75 percent / tetrabutylammonium hydrogeno-sulfate, 50percent NaOH / CHCl₃ / 2 h / Ambient temperature

4: 75 percent / 3N HCl / acetonitrile / 4 h / 50 °C

5: 90 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

6: 85 percent / pyridine, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium iodide; In diethyl ether; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)86814-9

Reference yield:

: 112775-74-3
(2'S,4S)-(+)-methyl-2'-(2,2-dimethyl-1,3-dioxolan-4-yl)-propanoate

: 112775-80-1
(1S,2R,4R,5R)-5-ethyl-2-methyl-4-tosyloxymethyl-6,8-dioxabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

2: 90 percent / pyridine / 2 h / 0 °C

3: 98 percent / sodium iodide / acetone / 24 h

4: 75 percent / tetrabutylammonium hydrogeno-sulfate, 50percent NaOH / CHCl₃ / 2 h / Ambient temperature

5: 75 percent / 3N HCl / acetonitrile / 4 h / 50 °C

6: 90 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

7: 85 percent / pyridine, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium iodide; In diethyl ether; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)86814-9