cyclohexyl-(4-nitrophenyl)methane

Base Information

• Chemical Name: cyclohexyl-(4-nitrophenyl)methane
• CAS No.: 145071-78-9
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 145071-78-9.mol

Synonyms:cyclohexyl-(4-nitrophenyl)methane

Chemical Property of cyclohexyl-(4-nitrophenyl)methane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclohexyl-(4-nitrophenyl)methane

There total 4 articles about cyclohexyl-(4-nitrophenyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(cyclohexylmethyl)benzene (4410-75-7) → cyclohexyl-(4-nitrophenyl)methane (145071-78-9)

Guidance literature:

With nitric acid; acetic anhydride; for 2h; Ambient temperature;

DOI:10.1016/0223-5234(92)90188-7

Reference yield:

Cyclohexyl phenyl ketone (712-50-5) → cyclohexyl-(4-nitrophenyl)methane (145071-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 1.) reflux, 1.5, 2.) 195 deg C, 4 h

2: 49 percent / HNO₃, acetic anhydride / 2 h / Ambient temperature

With potassium hydroxide; nitric acid; acetic anhydride; hydrazine hydrate; In diethylene glycol;

DOI:10.1016/0223-5234(92)90188-7

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → cyclohexyl-(4-nitrophenyl)methane (145071-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / 16 h / Ambient temperature

2: 85 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 1.) reflux, 1.5, 2.) 195 deg C, 4 h

3: 49 percent / HNO₃, acetic anhydride / 2 h / Ambient temperature

With potassium hydroxide; aluminium trichloride; nitric acid; acetic anhydride; hydrazine hydrate; In diethylene glycol;

DOI:10.1016/0223-5234(92)90188-7

upstream raw materials:

(cyclohexylmethyl)benzene

Cyclohexyl phenyl ketone

benzene

cyclohexylmagnesiumchloride

Downstream raw materials:

(4-aminophenyl)cyclohexylmethane

Refernces

• 1、 Hartmann,Batzl. "Synthesis and evaluation of 4-alkylanilines as mammary tumor inhibiting aromatase inhibitors". . p. 537 - 544. Retrieved 2007/10/02.