C₂HF₃O₂*C₃₇H₃₉N₅O₆S

Base Information

• Chemical Name: C₂HF₃O₂*C₃₇H₃₉N₅O₆S
• CAS No.: 1354577-92-6
• Molecular Formula: C₂HF₃O₂*C₃₇H₃₉N₅O₆S
• Molecular Weight: 795.837
• Mol file: 1354577-92-6.mol

Synonyms:C₂HF₃O₂*C₃₇H₃₉N₅O₆S

Chemical Property of C₂HF₃O₂*C₃₇H₃₉N₅O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₂HF₃O₂*C₃₇H₃₉N₅O₆S

There total 7 articles about C₂HF₃O₂*C₃₇H₃₉N₅O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H30N2O7S (1354578-46-3) + trifluoroacetic acid (76-05-1) + 4-(aminomethyl)benzene-1-carboximidamide dihydrochloride (217313-79-6) → C2HF3O2*C37H39N5O6S (1354577-92-6)

Guidance literature:

C₂₉H₃₀N₂O₇S; 4-(aminomethyl)benzene-1-carboximidamide dihydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

Boc-D-Tyr(All)-OH (350820-56-3) → C2HF3O2*C37H39N5O6S (1354577-92-6)

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / Cooling with ice

2: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere; Reflux

3: hydrogenchloride; acetic acid / 1 h

4: sodium hydroxide / acetonitrile; water / 4.5 h / pH 7 - 8

5: sodium hydroxide; water / 1,4-dioxane / 1 h / 40 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Grubbs catalyst first generation; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

Boc-D-Tyr(All)-Tyr(All)-OMe (1354578-42-9) → C2HF3O2*C37H39N5O6S (1354577-92-6)

Guidance literature:

Multi-step reaction with 5 steps

1: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere; Reflux

2: hydrogenchloride; acetic acid / 1 h

3: sodium hydroxide / acetonitrile; water / 4.5 h / pH 7 - 8

4: sodium hydroxide; water / 1,4-dioxane / 1 h / 40 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Grubbs catalyst first generation; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

C₂₉H₃₀N₂O₇S

trifluoroacetic acid

4-(aminomethyl)benzene-1-carboximidamide dihydrochloride

(S)-O-allyl-tyrosine methyl ester