tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate
CAS No.:1397708-91-6
Molecular Formula:C₃₇H₄₁F₄N₅O₅
Molecular Weight:711.757
Hs Code.:

tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

Synonyms:tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 220227-47-4
(4-fluoro-3-trifluoromethyl-phenyl)-acetic acid

: 1397708-90-5
tert-butyl 4-[({1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}amino)methyl]piperidine-1-carboxylate

: 1397708-91-6
tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

Guidance literature:: (4-fluoro-3-trifluoromethyl-phenyl)-acetic acid; With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

tert-butyl 4-[({1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}amino)methyl]piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 45 ℃; for 24h; Inert atmosphere;
DOI:10.1002/cmdc.201200184

Reference yield:

: 5345-47-1
2-aminopyridin-3-carboxylic acid

: 1397708-91-6
tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 20 h / -20 - 20 °C

1.2: 24 h / 20 °C

1.3: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane

3.1: 1,2-dichloro-ethane / 1 h

3.2: 2 h / 20 °C

4.1: 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 24 h / 45 °C / Inert atmosphere

With 4-methyl-morpholine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200184

Reference yield:

: 156-43-4
4-Ethoxyaniline

: 1397708-91-6
tert-butyl 4-[(N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 20 h / -20 - 20 °C

1.2: 24 h / 20 °C

1.3: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane

3.1: 1,2-dichloro-ethane / 1 h

3.2: 2 h / 20 °C

4.1: 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 24 h / 45 °C / Inert atmosphere

With 4-methyl-morpholine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200184