{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

Base Information

Chemical Name:{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide
CAS No.:1100393-07-4
Molecular Formula:C₂₀H₁₃ClF₄N₂O₂
Molecular Weight:424.782
Hs Code.:

Synonyms:{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

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Chemical Property of {3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

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Technology Process of {3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

There total 1 articles about {3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600730-94-7
3-[1-(2-Fluoro-5-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionic acid

: 20925-27-3
4-amino-2-chlorobenzonitrile

: 1100393-07-4
{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

Guidance literature:: 3-[1-(2-Fluoro-5-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionic acid; With thionyl chloride; N,N-dimethyl acetamide; at -10 ℃; for 1h;

4-amino-2-chlorobenzonitrile; In ISOPROPYLAMIDE; at -10 - 23 ℃; for 2h;

Reference yield:

: 1100393-07-4
{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide

: 536-74-3
phenylacetylene

: 1098075-01-4,1098074-99-7,1098075-00-3
rac-{2-hydroxy-3-[1-(2-fluoro-5-trifluoromethylphenyl)-cyclopropyl]-2-phenylethynylpropionic acid} (3-chloro-4-cyanophenyl)amide

Guidance literature:: phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

{3-[1-(2-fluoro-5-trifluoromethylphenyl)cyclopropyl]-2-oxopropionic acid} (3-chloro-4-cyanophenyl)amide; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 13h;

With water; ammonium chloride; In tetrahydrofuran; hexane;