N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine

Base Information

• Chemical Name: N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine
• CAS No.: 1268729-62-9
• Molecular Formula: C₂₅H₃₉N₃O₇
• Molecular Weight: 493.601
• Mol file: 1268729-62-9.mol

Synonyms:N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine

Chemical Property of N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine

There total 7 articles about N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate (1268729-61-8) → N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine (1268729-62-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 12h;

DOI:10.1002/hlca.201100437

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine (1268729-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

2: water; lithium hydroxide / tetrahydrofuran

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;

DOI:10.3390/md10061307

Reference yield:

methyl N-Methyl-D-valinate (769890-37-1) → N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine (1268729-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

2: water; lithium hydroxide / tetrahydrofuran

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;

DOI:10.3390/md10061307

upstream raw materials:

methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

Boc-Lys(Z)-OH

Boc-D-Val-OH

methyl N-Methyl-D-valinate

Downstream raw materials:

C₂₉H₄₆N₄O₈

methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate