Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate

Base Information

Chemical Name:Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate
CAS No.:80360-08-3
Molecular Formula:C24H29N7O5
Molecular Weight:495.531
Hs Code.:

Synonyms:SCHEMBL10688663;ZFWPBCDEDNIZTL-SFHVURJKSA-N;Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate;Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidine-6-yl)methylamino]benzoyl]-L-glutamate

Suppliers and Price of Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.347g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:13
Exact Mass:495.22301705
Heavy Atom Count:36
Complexity:734

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CCC(C(=O)OCC)NC(=O)C1=CC=C(C=C1)NCC2=CC3=C(N=C(N=C3N=C2)N)N
Isomeric SMILES:CCOC(=O)CC[C@@H](C(=O)OCC)NC(=O)C1=CC=C(C=C1)NCC2=CC3=C(N=C(N=C3N=C2)N)N

Technology Process of Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate

There total 16 articles about Diethyl N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 80360-04-9
2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine

: 80360-08-3
N-<4-<<(2,4-diaminopyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: With hydrogen; acetic acid; nickel; at 25 ℃; for 17h;
DOI:10.1021/jo00344a002

Reference yield: 14.0%

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 101810-72-4
2,4-diaminopyrido<2,3-d>pyrimidine-6-carbonitrile

: 80360-08-3
N-<4-<<(2,4-diaminopyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: With hydrogen; acetic acid; nickel; at 20 - 23 ℃; for 14h; under 724.007 - 775.7 Torr;
DOI:10.1021/jm00156a029

Reference yield:

: 101348-01-0
5-cyano-1,3-bis(methoxymethyl)uracil

: 80360-08-3
N-<4-<<(2,4-diaminopyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 85 percent / NaOEt / ethanol / 1 h / Ambient temperature

2: 1.) NaNO₂, HCl, 2.) HCl, H₂O / 1.) water, 2.5 h, 2.) 1 h

3: 88 percent / MgO, H₂ / 10percent Pd/C / dioxane / 2585.7 Torr

4: 84 percent / H₂ / Raney Ni / acetic acid / 2585.7 Torr

5: 89 percent / NaNO₂, AcOH, Ac₂O / 2 h / Ambient temperature

6: 90 percent / Heating

7: 83 percent / BCl₃ / CH₂Cl₂ / a) -78 deg C, 3 h, b) RT, overnight

8: 80 percent / pyridine / 48 h / Ambient temperature

9: p-TsOH, hexamethyldisilazane, NH₃ / 120 h / 155 - 160 °C

10: 50percent aq. MeOH / 4 h / Heating

11: HBr / dioxane / 20 h

12: N,N-dimethyl-acetamide / 72 h / Ambient temperature

With pyridine; hydrogenchloride; methanol; ammonia; water; hydrogen bromide; hydrogen; sodium ethanolate; acetic anhydride; magnesium oxide; boron trichloride; toluene-4-sulfonic acid; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite; palladium on activated charcoal; nickel; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; acetic acid;
DOI:10.1021/jm00155a021