1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

Base Information

Chemical Name:1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine
CAS No.:1227159-15-0
Molecular Formula:C₂₇H₂₉F₃N₈O₂S
Molecular Weight:586.641
Hs Code.:

1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

Synonyms:1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

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Chemical Property of 1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

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Technology Process of 1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

There total 4 articles about 1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1227160-33-9
1-[4-(chloromethyl)pyridin-2-yl]-4-cyclopropylpiperazine

: 1227160-31-7
5-(5-methyl-1H-pyrazol-3-yl)-3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazole

: 1227159-15-0
1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 25h; Reflux;

Reference yield:

: 100704-10-7
(2-chloropyridin-4-yl)methanol

: 1227159-15-0
1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 150 °C

2.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve

2.2: 2 h / Reflux

3.1: thionyl chloride / dichloromethane / 4.67 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 25 h / 0 °C / Reflux

With thionyl chloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1227160-34-0
[2-(piperazin-1-yl)pyridin-4-yl]methanol

: 1227159-15-0
1-cyclopropyl-4-(4-{[5-methyl-3-(3-{4-[N-methyl-S-(trifluoromethyl)sulfonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-yl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve

1.2: 2 h / Reflux

2.1: thionyl chloride / dichloromethane / 4.67 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 25 h / 0 °C / Reflux

With thionyl chloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;