(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

Base Information

Chemical Name:(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline
CAS No.:114885-96-0
Molecular Formula:C₂₁H₂₄N₂O₂
Molecular Weight:336.434
Hs Code.:

Synonyms:(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

Chemical Property:

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Technology Process of (+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

There total 4 articles about (+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-<<<9-(metoxymethyl)-1-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carbolin-2-yl>methyl>imino>valinol tert-butyl ether

: 114885-96-0
(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

Guidance literature:: With hydrazine hydrate; acetic acid; In ethanol; water; at 0 ℃;
DOI:10.1021/ja00222a041

Reference yield:

: 16502-01-5
tetrahydrobetacarboline

: 114885-96-0
(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / camphorsulfonic acid / toluene / 48 h / Heating

2: 1.) potassium hydride; 2.) tetramethylethylenediamine / 1.) THF, 0 deg C, 1 h; 2.) THF, 0 deg C, 1.5 h

3: 1.) tert-butyllithium / 1.) hexane, THF, -80 deg C, 30 min; 2.) hexane, THF, -80 deg C, 12 h

4: 97 percent / hydrazine monohydrate, acetic acid / ethanol; H₂O / 0 °C

With N,N,N,N,-tetramethylethylenediamine; camphor-10-sulfonic acid; tert.-butyl lithium; potassium hydride; hydrazine hydrate; acetic acid; In ethanol; water; toluene;
DOI:10.1021/ja00222a041

Reference yield:

: 99571-63-8
2-<<(1,2,3,4-tetrahydro-β-carbolin-2-yl)methyl>imino>valinol tert-butyl ether

: 114885-96-0
(+)-9-(metoxymethyl)-1(S)-(3-methoxybenzyl)-1,2,3,4-tetrahydro-β-carboline

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium hydride; 2.) tetramethylethylenediamine / 1.) THF, 0 deg C, 1 h; 2.) THF, 0 deg C, 1.5 h

2: 1.) tert-butyllithium / 1.) hexane, THF, -80 deg C, 30 min; 2.) hexane, THF, -80 deg C, 12 h

3: 97 percent / hydrazine monohydrate, acetic acid / ethanol; H₂O / 0 °C

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; potassium hydride; hydrazine hydrate; acetic acid; In ethanol; water;
DOI:10.1021/ja00222a041