(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Base Information

Chemical Name:(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide
CAS No.:1417654-15-9
Molecular Formula:C₂₀H₂₃I₂N₃O₄
Molecular Weight:623.229
Hs Code.:

Synonyms:(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Suppliers and Price of (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Chemical Property:

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Technology Process of (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

There total 8 articles about (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428317-56-9
C₃₃H₃₉I₂N₃O₇

: 1417654-15-9
(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; for 0.5h;

Reference yield:

: 1041-01-6,534-51-0,5563-89-3,299-82-1
3,5-diiodo-L-thyronine

: 1417654-15-9
(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran; 1,4-dioxane / 20 °C / Inert atmosphere; Cooling with ice

1.2: 3 h / pH 9 - 9.5

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

4.1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

6.1: dmap / N,N-dimethyl-formamide

7.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h

With triethylsilane; dmap; lithium borohydride; chloro-trimethyl-silane; sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417654-00-2
(S)-tert-butyl (1-hydroxy-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propan-2-yl)carbamate

: 1417654-15-9
(S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

3: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

4: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

5: dmap / N,N-dimethyl-formamide

6: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h

With triethylsilane; dmap; sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;