N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

Base Information

Chemical Name:N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine
CAS No.:199108-87-7
Molecular Formula:C₂₆H₃₄ClNO₂
Molecular Weight:428.014
Hs Code.:

Synonyms:N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

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Chemical Property of N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

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Technology Process of N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

There total 3 articles about N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 199108-75-3
N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(2S)-pyrrolidine-2-methanol

: 199108-87-7
N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

Guidance literature:: With thionyl chloride; In benzene; at 25 ℃; for 1h;
DOI:10.1021/jm9805541

Reference yield:

: 138564-72-4
(2RS)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl methanesulphonate

: 199108-87-7
N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 6 h / 120 °C

2: 73 percent / SOCl₂ / benzene / 1 h / 25 °C

With thionyl chloride; In benzene; 1: Substitution / 2: Rearrangement;
DOI:10.1021/jm9805541

Reference yield:

: 171270-07-8
(6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol

: 199108-87-7
N-[(2R/S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethyl]-(3R)-3-chloropiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 75 percent / 6 h / 120 °C

3: 73 percent / SOCl₂ / benzene / 1 h / 25 °C

With thionyl chloride; triethylamine; In dichloromethane; benzene; 1: mesylation / 2: Substitution / 3: Rearrangement;
DOI:10.1021/jm9805541