2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

Base Information

Chemical Name:2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide
CAS No.:1400690-98-3
Molecular Formula:C₂₉H₃₃N₇O₃
Molecular Weight:527.626
Hs Code.:

Synonyms:2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

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Chemical Property of 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

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Technology Process of 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

There total 6 articles about 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400690-97-2
2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}benzonitrile

: 1400690-98-3
2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In dimethyl sulfoxide; at 40 - 90 ℃; for 19h;

Reference yield:

: 1400690-95-0
methyl-(Z)-3-amino-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-hexenoate

: 1400690-98-3
2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 16 h / 50 °C

2.1: trimethylaluminum / 1,2-dichloro-ethane; hexane / 1.17 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Reflux

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 19 h / 40 - 90 °C

With hydroxylamine hydrochloride; trimethylaluminum; sodium hydrogencarbonate; triethylamine; In hexane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: methyl (Z)-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-3-isobutylamide-2-hexenoate

: 1400690-98-3
2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N'-hydroxybenzimidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / 1,2-dichloro-ethane; hexane / 1.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Reflux

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 19 h / 40 - 90 °C

With hydroxylamine hydrochloride; trimethylaluminum; sodium hydrogencarbonate; In hexane; dimethyl sulfoxide; 1,2-dichloro-ethane;