Technology Process of 7-methoxy-1-phenyl-3,4-dihydroquinolin-2(1H)-one
There total 4 articles about 7-methoxy-1-phenyl-3,4-dihydroquinolin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2-chloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-propenamide;
With
potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; bis(η3-allyl-μ-chloropalladium(II)); XPhos;
In
methanol; tert-Amyl alcohol;
at 110 ℃;
for 16h;
Inert atmosphere;
Sealed tube;
iodobenzene;
With
potassium phosphate; copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane;
In
methanol; tert-Amyl alcohol;
at 20 - 130 ℃;
for 16.17h;
Inert atmosphere;
Sealed tube;
Molecular sieve;
DOI:10.1021/ol4006008
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
2.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; bis(η3-allyl-μ-chloropalladium(II)); XPhos; potassium phosphate / tert-Amyl alcohol; methanol / 16 h / 110 °C / Inert atmosphere; Sealed tube
2.2: 16.17 h / 20 - 130 °C / Inert atmosphere; Sealed tube; Molecular sieve
With
potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; XPhos;
In
1,4-dioxane; methanol; tert-Amyl alcohol;
DOI:10.1021/ol4006008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: zirconium(IV) chloride; N-chloro-succinimide / dichloromethane
2.1: diisopropylamine / dichloromethane
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; bis(η3-allyl-μ-chloropalladium(II)); XPhos; potassium phosphate / tert-Amyl alcohol; methanol / 16 h / 110 °C / Inert atmosphere; Sealed tube
4.2: 16.17 h / 20 - 130 °C / Inert atmosphere; Sealed tube; Molecular sieve
With
potassium phosphate; N-chloro-succinimide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; zirconium(IV) chloride; diisopropylamine; XPhos;
In
1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane;
DOI:10.1021/ol4006008
