(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Base Information

Chemical Name:(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)
CAS No.:1446417-04-4
Molecular Formula:C₅₆H₄₆N₄O₆S₂
Molecular Weight:935.136
Hs Code.:

Synonyms:(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

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Chemical Property of (2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

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Technology Process of (2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

There total 3 articles about (2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2799-07-7
S-trityl-L-cysteine

: 219134-87-9
<2,2'-bipyridine>-5,5'-dicarboxylic acid bis(N-hydroxysuccinimide) ester

: 1446417-04-4
(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1055/s-0032-1318407

Reference yield:

: 1802-30-8
2,2'-bipyridine-5,5'-dicarboxylic acid

: 1446417-04-4
(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; chlorobenzene; trifluoroacetic anhydride / ethyl acetate; 1,4-dioxane / 16.25 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With pyridine; triethylamine; chlorobenzene; trifluoroacetic anhydride; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1318407

Reference yield:

: 1762-34-1
5,5'-dimethyl-2,2'-bipyridine

: 1446417-04-4
(2R,2'R)-2,2'-(([2,2'-bipyridine]-5,5'-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 0 °C / Inert atmosphere

1.2: 22 h / 0 - 75 °C / Inert atmosphere

2.1: pyridine; chlorobenzene; trifluoroacetic anhydride / ethyl acetate; 1,4-dioxane / 16.25 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With pyridine; sulfuric acid; triethylamine; chlorobenzene; trifluoroacetic anhydride; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1318407