(2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name)

Base Information

Chemical Name:(2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name)
CAS No.:745035-16-9
Molecular Formula:C₁₉H₂₆N₂O₉
Molecular Weight:426.423
Hs Code.:

(2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name)

Synonyms:

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Chemical Property of (2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name)

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name)

There total 3 articles about (2R,4S,5R,6R)-5-(acetylamino)-2-(3,4-dihydro-2H-pyrano[3,2-c]pyridin-6-ium-6-yl)-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: N-[methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dihydro-2'H-pyrano[3',2'-c]pyridinium tetrafluoroborate

: 745035-16-9
N-[(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dihydro-2'H-pyrano[3',2'-c]pyridinium

Guidance literature:: N-[methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dihydro-2'H-pyrano[3',2'-c]pyridinium tetrafluoroborate; With sodium methylate; In methanol;

With sodium hydroxide; In water;
DOI:10.1002/poc.776

Reference yield:

: 57446-02-3
3,4-dihydro-2H-pyrano[3,2-c]pyridine

: 745035-16-9
N-[(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dihydro-2'H-pyrano[3',2'-c]pyridinium

Guidance literature:: Multi-step reaction with 2 steps

1.1: 44 percent / 4 Angstroem molecular sieves; silver tetrafluoroborate / tetrahydrofuran / 60 h / 20 °C

2.1: NaOMe / methanol

2.2: 25 percent / NaOH / H₂O

With silver tetrafluoroborate; 4 A molecular sieve; sodium methylate; In tetrahydrofuran; methanol;
DOI:10.1002/poc.776

Reference yield:

: 67670-69-3
N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester

: 745035-16-9
N-[(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dihydro-2'H-pyrano[3',2'-c]pyridinium

Guidance literature:: Multi-step reaction with 2 steps

1.1: 44 percent / 4 Angstroem molecular sieves; silver tetrafluoroborate / tetrahydrofuran / 60 h / 20 °C

2.1: NaOMe / methanol

2.2: 25 percent / NaOH / H₂O

With silver tetrafluoroborate; 4 A molecular sieve; sodium methylate; In tetrahydrofuran; methanol;
DOI:10.1002/poc.776