(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

Base Information

Chemical Name:(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid
CAS No.:1429347-09-0
Molecular Formula:C₂₃H₃₂N₂O₅S
Molecular Weight:448.583
Hs Code.:

Synonyms:(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

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Chemical Property of (R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

Chemical Property:

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Technology Process of (R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

There total 4 articles about (R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16504-57-7
(S)-3-amino-4-hydroxybutanoic acid

: 1429347-59-0
N-(2,4-dimethylphenyl)-4-fluoro-N-isobutyl-3-methylbenzenesulfonamide

: 1429347-09-0
(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 122h; Inert atmosphere;

Reference yield:

: (2,4-dimethylphenyl)(2-methylpropyl)amine

: 1429347-09-0
(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C

2: sodium hydride / dimethyl sulfoxide; mineral oil / 122 h / 20 °C / Inert atmosphere

With pyridine; sodium hydride; In dimethyl sulfoxide; mineral oil;

Reference yield:

: 95-66-9
2,4-dimethylchlorobenzene

: 1429347-09-0
(R)-3-((4-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)-2-methylphenyl)amino)-4-hydroxybutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane; {1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinyl}(chloro)(2-methyl-2-propen-1-yl)palladium / tetrahydrofuran / 0.75 h / 70 °C / Inert atmosphere; Sealed tube

2: pyridine / 16 h / 20 °C

3: sodium hydride / dimethyl sulfoxide; mineral oil / 122 h / 20 °C / Inert atmosphere

With pyridine; {1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinyl}(chloro)(2-methyl-2-propen-1-yl)palladium; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;