Technology Process of 2-(2-methoxy-3-methylphenyl)ethyl methylsulfinylmethyl ketone
There total 5 articles about 2-(2-methoxy-3-methylphenyl)ethyl methylsulfinylmethyl ketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
2: 89 percent / benzyltributylammonium chloride, aq. KOCl / ethyl acetate / 0.4 h
3: 94 percent / piperidine, pyridine / a) 85 deg C, 2 h, b) 115 deg C, 2 h
4: 99 percent / H2 / 10percent Pd/C / ethanol / 1 h / 2844.3 Torr
5: 99 percent / H2SO4 conc. / benzene / 36 h / Heating
6: 1.) NaH / 1.) 55 - 70 deg C, 2.5 h, 2.) THF, RT, 3 h
With
piperidine; pyridine; potassium hypochlorite; sulfuric acid; hydrogen; benzyltri(n-butyl)ammonium chloride; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride;
palladium on activated charcoal;
In
ethanol; ethyl acetate; benzene;
DOI:10.1021/jm00181a010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / piperidine, pyridine / a) 85 deg C, 2 h, b) 115 deg C, 2 h
2: 99 percent / H2 / 10percent Pd/C / ethanol / 1 h / 2844.3 Torr
3: 99 percent / H2SO4 conc. / benzene / 36 h / Heating
4: 1.) NaH / 1.) 55 - 70 deg C, 2.5 h, 2.) THF, RT, 3 h
With
piperidine; pyridine; sulfuric acid; hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol; benzene;
DOI:10.1021/jm00181a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / H2 / 10percent Pd/C / ethanol / 1 h / 2844.3 Torr
2: 99 percent / H2SO4 conc. / benzene / 36 h / Heating
3: 1.) NaH / 1.) 55 - 70 deg C, 2.5 h, 2.) THF, RT, 3 h
With
sulfuric acid; hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol; benzene;
DOI:10.1021/jm00181a010
