Technology Process of 2'-C-methylcytidine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]
There total 12 articles about 2'-C-methylcytidine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
triethylammonium 2-(2,2-dimethyl-3-(trityloxy)propanoylthio)ethyl phosphonate;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
acetonitrile;
at 41 - 46 ℃;
benzylamine;
In
tetrachloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dichloromethane / 1.5 h / 15 - 25 °C / Inert atmosphere; Large scale; Green chemistry
2: phosphorous acid; pivaloyl chloride / dichloromethane / 2 h / 20 - 25 °C / Inert atmosphere; Large scale; Green chemistry
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / acetonitrile / 4 h / 41 - 46 °C / Inert atmosphere; Green chemistry
4: tetrachloromethane / acetonitrile / 1 h / 20 °C / Inert atmosphere; Green chemistry
5: citric acid / acetonitrile; water; ethyl acetate / pH 4 / Inert atmosphere; Green chemistry
With
pyridine; tetrachloromethane; pivaloyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; phosphorous acid;
In
dichloromethane; water; ethyl acetate; acetonitrile;
4: |Atherton-Todd Synthesis;
DOI:10.1021/op500042u
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dichloromethane / 1 h / 20 - 25 °C / Inert atmosphere; Large scale; Green chemistry
2: dichloromethane / 1.5 h / 15 - 25 °C / Inert atmosphere; Large scale; Green chemistry
3: phosphorous acid; pivaloyl chloride / dichloromethane / 2 h / 20 - 25 °C / Inert atmosphere; Large scale; Green chemistry
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / acetonitrile / 4 h / 41 - 46 °C / Inert atmosphere; Green chemistry
5: tetrachloromethane / acetonitrile / 1 h / 20 °C / Inert atmosphere; Green chemistry
6: citric acid / acetonitrile; water; ethyl acetate / pH 4 / Inert atmosphere; Green chemistry
With
pyridine; tetrachloromethane; pivaloyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; phosphorous acid;
In
dichloromethane; water; ethyl acetate; acetonitrile;
5: |Atherton-Todd Synthesis;
DOI:10.1021/op500042u
