2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide
CAS No.:1599475-11-2
Molecular Formula:C₁₉H₁₂F₂N₄OS₂
Molecular Weight:414.459
Hs Code.:

Synonyms:2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

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Chemical Property of 2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

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Technology Process of 2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

There total 4 articles about 2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1599475-35-0
C₈H₈BN₃O₂S

: 1599475-28-1
C₁₁H₆BrF₂NOS

: 1599475-11-2
2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; acetonitrile; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1599475-27-0
C₁₃H₈BrF₂NO₂S

: 1599475-11-2
2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol; tetrahydrofuran / 0.5 h / 20 °C

2: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 166196-73-2,942223-95-2
2-(1H-pyrazol-3-yl)-1,3-thiazole

: 1599475-11-2
2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydride; In tetrahydrofuran; 1,4-dioxane; acetonitrile;