tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate
CAS No.:1093397-82-0
Molecular Formula:C₃₁H₃₆N₄O₆
Molecular Weight:560.65
Hs Code.:

Synonyms:tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(amino-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1093395-66-4
4-(5-cyano-7-isopropyl-benzooxazol-2-yl)-benzoic acid

: 1093397-82-0
tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 1689-84-5
Bromoxynil

: 1093397-82-0
tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; sodium nitrite / 50 °C

2.1: pyrographite / iron(III) chloride / methanol / 0.25 h / 65 °C

2.2: 2 h / Reflux

3.1: 1,4-dioxane / Reflux

3.2: Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 91 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 60 °C / 517.16 Torr

6.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 50 °C

6.2: 0.08 h

7.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C

With lithium hydroxide monohydrate; hydrogen; sodium carbonate; pyrographite; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium nitrite; iron(III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 862730-24-3
3-amino-5-bromo-4-hydroxybenzonitrile

: 1093397-82-0
tert-butyl 4-(1-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / Reflux

1.2: Reflux

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 91 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 60 °C / 517.16 Torr

4.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 50 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C

With lithium hydroxide monohydrate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;