1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

Base Information

• Chemical Name: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
• CAS No.: 821794-92-7
• Molecular Formula: C₁₈H₁₉FN₄O₂
• Molecular Weight: 342.373
• Hs Code.: 2933998090
• Mol file: 821794-92-7.mol

Synonyms:1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-6-yl]-2-fluoroethanone;

Chemical Property of 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

Chemical Property:

• Vapor Pressure: 6.57E-17mmHg at 25°C
• Boiling Point: 633.3°Cat760mmHg
• Flash Point: 336.8°C
• PSA: 94.03000
• Density: 1.36g/cm³
• LogP: 3.10470
• Solubility.: insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥28.7 mg/mL in EtOH

Purity/Quality:

97% ^*data from raw suppliers

FMK ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: FMK is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

Technology Process of 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

There total 1 articles about 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H33FN4O2Si → FMK (821794-92-7)

Guidance literature:

C₂₄H₃₃FN₄O₂Si; With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; for 3h;

With sodium hydrogencarbonate; sodium chloride; In tetrahydrofuran; water; ethyl acetate;

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