2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

Base Information

Chemical Name:2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile
CAS No.:1198211-94-7
Molecular Formula:C₂₈H₂₂ClN₅OS₂
Molecular Weight:544.101
Hs Code.:

Synonyms:2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

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Chemical Property of 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

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Technology Process of 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

There total 4 articles about 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol

: 1163271-48-4
2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-phenylpyridine-3,5-dicarbonitrile

: 1198211-94-7
2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

Guidance literature:: 1-methyl-3-pyrrolidinol; With phosphazene base-P₄-tert-butyl; In tetrahydrofuran; for 0.166667h;

2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-phenylpyridine-3,5-dicarbonitrile; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 17969-22-1
4-chloromethyl-2-(4-chloro-phenyl)-thiazole

: 1198211-94-7
2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

2.1: copper dichloride; isopentyl nitrite / acetonitrile / 4 h / 60 °C

3.1: phosphazene base-P₄-tert-butyl / tetrahydrofuran / 0.17 h

3.2: 20 °C

With sodium hydrogencarbonate; phosphazene base-P₄-tert-butyl; copper dichloride; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1163175-96-9
2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-phenylpyridine-3,5-dicarbonitrile

: 1198211-94-7
2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-6-[(1-methylpyrrolidin-3-yl)oxy]-4-phenylpyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper dichloride; isopentyl nitrite / acetonitrile / 4 h / 60 °C

2.1: phosphazene base-P₄-tert-butyl / tetrahydrofuran / 0.17 h

2.2: 20 °C

With phosphazene base-P₄-tert-butyl; copper dichloride; isopentyl nitrite; In tetrahydrofuran; acetonitrile;