Q₂FA₁₆

Base Information

• Chemical Name: Q₂FA₁₆
• CAS No.: 887604-26-4
• Molecular Formula: C₂₄H₄₂O₃
• Molecular Weight: 378.596
• Mol file: 887604-26-4.mol

Synonyms:Q₂FA₁₆

Chemical Property of Q₂FA₁₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Q₂FA₁₆

There total 7 articles about Q₂FA₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(16-Benzyloxy-hexadec-1-ynyl)-1,4-dimethoxy-benzene (887604-11-7) → Q2FA16 (887604-26-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2006.02.041

Reference yield:

hexadec-15-ynyloxymethyl-benzene (887604-06-0) → Q2FA16 (887604-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; Pd(PPh₃)4 / 24 h / 80 °C

2: H₂ / Pd/C / ethanol / 20 °C

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; palladium on activated charcoal; In ethanol; 1: Sonogashira cross-coupling;

DOI:10.1016/j.bmcl.2006.02.041

Reference yield:

14-bromotetradecan-1-ol (72995-94-9) → Q2FA16 (887604-26-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: tetrahydrofuran / 24 h / Heating

2.1: dimethylsulfoxide / 0 - 20 °C

3.1: piperidine; Pd(PPh₃)4 / 24 h / 80 °C

4.1: H₂ / Pd/C / ethanol / 20 °C

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide; 3.1: Sonogashira cross-coupling;

DOI:10.1016/j.bmcl.2006.02.041

upstream raw materials:

2-(16-Benzyloxy-hexadec-1-ynyl)-1,4-dimethoxy-benzene

hexadec-15-ynyloxymethyl-benzene

14-bromotetradecan-1-ol

1,14-tetradecanediol

Refernces

• 1、 Hanbali, Mazen,Vela-Ruiz, Marta,Bagnard, Dominique,Luu, Bang. "Quinol fatty alcohols as promoters of axonal growth". . p. 2637 - 2640. Retrieved 2007/10/03.