[4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester
• CAS No.: 1036227-29-8
• Molecular Formula: C₁₅H₁₆FNO₃S
• Molecular Weight: 309.361
• Mol file: 1036227-29-8.mol

Synonyms:[4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester

Chemical Property of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester

There total 1 articles about [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 4-(4-fluorophenyl)thiazol-2-ol (834885-06-2) → [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester (1036227-29-8) + C15H16FNO3S

Guidance literature:

4-(4-fluorophenyl)thiazol-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

[4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester (1036227-29-8) → [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroactetate (1036227-31-2)

Guidance literature:

With water; trifluoroacetic acid; at 20 ℃; for 2h;

upstream raw materials:

bromoacetic acid tert-butyl ester

4-(4-fluorophenyl)thiazol-2-ol

Downstream raw materials:

[4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroactetate