2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

Base Information

Chemical Name:2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid
CAS No.:74667-34-8
Molecular Formula:C₂₆H₃₁NO₇
Molecular Weight:469.535
Hs Code.:

2-<cyano(1,4,5-trimethoxynaphth-2-yl)methyl>-4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

Synonyms:2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

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Chemical Property of 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

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Technology Process of 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

There total 12 articles about 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 73481-55-7
Ethyl 2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylate

: 74667-34-8
2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; ethanol; for 24h; Heating;
DOI:10.1021/ja00538a029

Reference yield:

: 71742-40-0,76184-49-1
ethyl 4-acetylcyclohexene-1-carboxylate

: 74667-34-8
2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) p-toluenesulfonic acid, 2.) lithium diisopropylamide / 1) benzene, reflux, 24 h; 2) THF, -78 deg C

2: 1.) potassium hydride / 1) THF, room temperature, 1 h; 2) HMPA, THF, -20 deg C (3 h), 0 deg C (3 h), room temperature (12 h)

3: 77 percent / aq. potassium hydroxide / tetrahydrofuran; ethanol / 24 h / Heating

With potassium hydroxide; potassium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00538a029

Reference yield:

: 66617-28-5
ethyl 4-(2-methyl-1,3-dioxolan-2-yl)cyclohexene-1-carboxylate

: 74667-34-8
2--4-(2-methyl-1,3-dioxolan-2-yl)cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium hydride / 1) THF, room temperature, 1 h; 2) HMPA, THF, -20 deg C (3 h), 0 deg C (3 h), room temperature (12 h)

2: 77 percent / aq. potassium hydroxide / tetrahydrofuran; ethanol / 24 h / Heating

With potassium hydroxide; potassium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00538a029